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Thursday 10 August 2006

Olanzapine differentially affects 5-HT2Aand2C receptor mRNA expression in the rat brain.

By: Huang XF, Han M, Huang X, Zavitsanou K, Deng C.

Behav Brain Res 2006 Aug 10;171(2):355-62

This study examined regional changes in rat brain mRNA levels encoding 5-HT(2A) and 5-HT(2C) receptors following chronic olanzapine treatment. The immediate effect (2h after the last treatment) was a down-regulation of 5-HT(2A) receptor mRNA expression, predominantly in the hypothalamus, limbic system and striatum, while a rebound effect was observed 48 h later. 5-HT(2C) receptor mRNA expressions were decreased in the substantia nigra. Correlations between 5-HT(2A) receptor mRNA expression and total food intake, weight gain and energy efficiency were observed.

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