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Thursday 01 November 2001

Opposite effects of olanzapine and haloperidol in rat ultrasonic vocalization test.

By: Siemiatkowski M, Maciejak P, Sienkiewicz-Jarosz H, Czlonkowska AI, Szyndler J, Gryczynska A, Plaznik A.

Pol J Pharmacol 2001 Nov-Dec;53(6):669-73

The opposite effects of the classical antipsychotic, haloperidol, and atypical neuroleptic, olanzapine, in the rat ultrasonic vocalization test of anxiety were observed. The present data are discussed in relation to growing body of evidence of specific brain biochemical changes after pretreatment with different antipsychotics.

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